New research suggests that individuals who stop using blockbuster weight-loss injections like Wegovy and Mounjaro can put back on shed pounds far faster than those who halt conventional diet and exercise plans.
Findings released in a prominent health publication demonstrates that while overweight people often shed a large proportion of their total mass while using the jabs, the mass comes back at an average rate of 0.8 kg per month upon discontinuation.
"Users buying such drugs need to be informed of the potential of quick rebound weight gain when the medication is stopped," cautioned researcher Dr. Susan Jebb.
Such speed of recovery means a reversion to starting mass in about one and a half years.
Comparing Approaches
The study, which examined dozens of studies involving over 9,000 of participants, contrasted the effects of these new drugs with older methods.
Scientists emphasize that people who shed pounds through diet and exercise usually experience a less rapid weight regain—perhaps 100 grams monthly—after stopping.
Understanding the Quick Rebound
Nutrition scientists suggest the way of the drugs is key to understanding the accelerated regain.
These medications mimic a body's own chemical called glucagon-like peptide-1, which moderates hunger.
"Sustained high doses of GLP-1 concentrations far above than normal could lead to the system to produce less of its own natural hormone, and may also reduce sensitivity to its effects," explained Dr. Adam Collins, a dietetics expert.
"Withdrawal of this medication leads to appetite is no longer kept in check, making overeating far more likely."
A Chronic Disease?
Medical guidelines advise the injections for individuals with weight-linked medical conditions, accompanied by recommended lifestyle changes.
Many experts contend that, due to the likelihood of relapse, the treatment is often ongoing.
This opinion is echoed by pharmaceutical companies, who say that the results "emphasize the long-term nature of excess weight," similar to managing diseases like hypertension.
User Experiences
Individuals who have stopped the jabs explain a sudden return of hunger.
"It was like something flipping and you're instantly extremely hungry," said an individual.
The struggle is worsened if individuals have not established sustainable lifestyle or habit modifications during therapy.
Widespread Adoption
Figures suggest that millions of people in the UK have used these injections in the last 12 months, with desire remaining high.
- Use is higher among females than men.
- The middle-aged age group shows the highest level of interest.
- Many obtain the drugs through private healthcare rather than the NHS.
Finally, experts stress that while GLP-1 drugs are potent agents for weight loss, they are not a permanent fix and maintained weight loss relies on integrated behavioural management.
